Arthritis at 45 — Dr. Aneesh Garg, DO, CAQ on What It Actually Means for Your Active Life

Tuesday - August 4, 2026

You just got told you have arthritis and you’re 45. The first thought is that your active life is over and you’re headed for a joint replacement. Dr. Aneesh Garg, DO, CAQ says that’s not even close to true — but the way most people respond to that diagnosis makes it worse. In this episode he breaks down why stopping exercise accelerates joint degeneration, why steroid injections speed up the arthritis train, and how a 45-year-old woman with a knee replacement scheduled for the following week cancelled her surgery and worked her way back to hiking and 10Ks using EMTT, focused shockwave, PRP, and stem cells.

Chapters

  • 0:03 Hook: You’re 45, not 75, and you just heard the word arthritis
  • 0:55 Am I headed for a joint replacement? No, full stop: arthritis is a spectrum
  • 3:13 Should I stop running? Why movement protects the joint and every extra pound counts
  • 6:07 The old paradigm: PT, steroid shot, replace the knee, and why I reject it
  • 8:10 The regenerative toolbox: EMTT, focused shockwave, PRP, hyaluronic acid, BMA and MFAT stem cells
  • 10:23 Your first visit, and the woman who canceled her knee replacement
  • 14:09 The implant lifespan math, and why you can’t come back from a knee replacement
  • 17:14 The day you get the diagnosis: don’t panic, don’t stop moving, don’t accept that answer

Questions this episode answers

Does arthritis at 45 mean I will need a knee replacement?

No. Full stop, no. Arthritis is a spectrum, and early arthritis tends to be manageable with a trajectory you can change. Between a diagnosis and a joint replacement there are years of interventions and options that most people are never told about. Being handed the word arthritis without being told what can be done about it is a failure in communication, not a verdict on your active life.

Should I stop running or working out if I have arthritis?

No. Activity is protective for your joints, and inactivity actually accelerates degeneration, so the worst thing you can do is stop moving. Cartilage has a poor blood supply and gets part of its nourishment from movement. When I compare runners with people who live a sedentary lifestyle, it is the runners who are more protected. The goal is not stopping, it is modifying how you move intelligently while we treat the injured tissue.

Does losing weight help knee arthritis?

Yes, and the math is simple. Every pound you carry above the knee acts like roughly four pounds of force on the knee joint, so an extra 10 pounds puts about 40 extra pounds through your knees and an extra 20 puts about 80. As the pounds add up, so does the force. Staying active and maintaining a healthy weight are two of the most protective things you can do for a knee with early arthritis.

What are the treatment options for early arthritis besides steroid injections and surgery?

The old paradigm was physical therapy, a steroid injection, and then a knee replacement when those stopped working. That masks symptoms. In my office we work on increasing blood flow and treating the joint with EMTT and focused shockwave, PRP, hyaluronic acid, and stem cells from bone marrow (BMA) or adipose tissue (MFAT). Which of those you need, alone or in combination, is decided at your exam based on how advanced the arthritis is and your own comfort level.

I’m 45 with a knee replacement on the calendar. What are my options first?

For many people it can delay a replacement or help them avoid it. Early in our practice a 45-year-old woman came to us with a knee replacement booked for the following week. We treated her knee with EMTT, focused shockwave, MFAT stem cells, PRP and hyaluronic acid, she canceled the surgery, and she went on to hike and start asking about a 5K and a 10K. She may still need a replacement someday, but she bought back years of activity.

Why did shockwave therapy hurt or not work for my arthritis?

Most likely because it was radial pressure wave, not focused shockwave. Radial should not be used on bone; it hurts, and when a clinic calls radial ‘shockwave,’ people walk away believing shockwave is painful or does not work. For arthritis I use EMTT and focused shockwave to increase blood flow and treat the joint. The device and the way it is applied matter as much as the name on the brochure.

Is it too late for regenerative medicine if my knee is bone-on-bone?

No. Waiting until you are bone-on-bone means you missed the window where we can make the biggest impact, but it does not mean nothing can be done. The same options still apply to you; we have simply waited longer than I would like. The earlier you start, the more joint function you preserve, so if you are early in the process treat this as time-sensitive, and if you are late, come in anyway.

What should I do the day I am diagnosed with arthritis?

Don’t panic, don’t stop moving, and don’t accept ‘we’ll just manage it’ or ‘you need a knee replacement’ as the end of the conversation. Take the diagnosis and ask what your other options are. Then see a regenerative medicine specialist who does this all day, every day, not someone who offers it on the side, and get an opinion from somebody who sees the whole picture instead of only the end stage.

What happens at a regenerative medicine consultation for early arthritis?

The first job is walking you off the ledge, because being saddled with an arthritis diagnosis at 45 is a big blow. We talk through what the diagnosis actually means for you, then look at lifestyle modifications and how to get you stronger through the hips to support the knee. From there we go through your options, from EMTT and focused shockwave to PRP, hyaluronic acid and stem cells, based on where you sit on the spectrum.

Does an ACL tear cause arthritis earlier?

It speeds up your arthritis clock. After an ACL tear there is a little bit of instability in the knee, and that instability accelerates wear in the joint, which is why, with more and more people getting injured, we are seeing arthritis show up earlier. If you have had a significant knee injury, do not wait for bone-on-bone to find out where you stand; early evaluation is where the options are widest.

Medical Disclaimer

The Regen Doc is for educational purposes only and does not constitute medical advice or create a physician-patient relationship. Patient stories are anonymized, individual results vary, and candidacy requires a formal consultation at DynamicAthlete.com.

The Regen Doc is for educational purposes only and does not constitute medical advice or create a physician-patient relationship. Individual results vary. Candidacy requires a formal consultation at DynamicAthlete.com.

Aneesh Garg, DO, CAQ, Research Director of the DART Lab at Dynamic Athlete in Boulder, Colorado

All Dynamic PRP+ and Dynamic Stem Cell+ procedures are performed exclusively by Dr. Garg. Dynamic Shockwave+, Dynamic Mind+, and Dynamic Core+ are performed by Dr. Garg and his clinical team.

Meet Dr. Garg

Aneesh Garg, DO, CAQ. Founder of Dynamic Athlete Sports Medicine and Regenerative Orthopaedics. Yale residency trained. Andrews Sports Medicine fellowship trained. Double board-certified Sports Medicine and Internal Medicine. Team Physician USA Hockey and U.S. Soccer. Founder and Medical Director of ASTI (American Shockwave Training Institute).

Teaching faculty RMTI and Rocky Vista University. Host of The Regen Doc podcast. Dr. Garg developed the Dynamic PRP+, Dynamic Stem Cell+, Dynamic Shockwave+, Dynamic Mind+, and Dynamic Core+ protocols used at this practice.

Why Patients Trust Dr. Garg

Yale residency trained. Andrews Sports Medicine fellowship trained. Double board-certified Sports Medicine and Internal Medicine.

Yale-New Haven Hospital residency

Fellowship-trained at the American Sports Medicine Institute (ASMI) / Andrews Sports Medicine

Team Physician for USA Hockey and U.S. Soccer

Medical Director of the American Shockwave Training Institute (ASTI), training clinicians nationwide in ESWT, RPW, and EMTT

Known for physician-performed, ultrasound-guided PRP, BMA/MFAT, and shockwave-primed biologic injections

The Regen Doc Podcast

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